Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Metazoan genomes are spatially organized at multiple scales, from packaging of DNA
around individual nucleosomes to segregation of whole chromosomes into distinct …

In this study, we describe the 3D chromosome regulatory landscape of human naive and
primed embryonic stem cells. To devise this map, we identified transcriptional enhancers …

Although population-level analyses revealed significant roles for CTCF and cohesin in
mammalian genome organization, their contributions at the single-cell level remain …

Cell fate transitions are accompanied by global transcriptional, epigenetic and topological
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

The genome of all organisms is spatially organized to function efficiently. The advent of
genome-wide chromatin conformation capture (Hi-C) methods has revolutionized our ability …

Background The relationship between transcription and the 3D chromatin structure is
debated. Multiple studies have shown that transcription affects global Cohesin binding and …

During the twentieth century, genes were considered the controlling force of life processes,
and the transfer of DNA the definitive explanation for biological heredity. Such views shaped …