Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream
activators of various significant signaling pathways. Hyperactivation of the PI3K/AKT/mTOR …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Regional metastasis of head and neck cancer (HNC) is prevalent (approximately 50% of
patients at diagnosis), yet the underlying drivers and mechanisms of lymphatic spread …

Human papilloma virus (HPV)-associated oropharyngeal cancer (OPC) is an independent
tumour type with regard to cellular, biological, and clinical features. The use of non-invasive …

Head and neck squamous cell carcinomas (HNSCC) are associated with significant
treatment-related morbidity and poor disease-free and disease-specific survival, especially …

Genomic alterations are a driving force in the multistep process of head and neck cancer
(HNC) and result from the interaction of exogenous environmental exposures and …

The characterization of immortalized canine osteosarcoma (OS) cell lines used for research
has historically been based on phenotypic features such as cellular morphology and …

Background Laryngeal squamous cell carcinomas (LSCCs) have a high risk of recurrence
and poor prognosis. Patient‐derived cancer cell lines remain important preclinical models …

Background Palbociclib is a selective inhibitor of CDK4/6 approved in metastatic breast
cancer as well as evidence of activity in malignancies with CDK4-amplifications. Extensive …

Background Currently, no clinically useful biomarkers for radioresistance are available in
head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of …