The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

Anatomical, electrophysiological and behavioral studies in rodents have shown that the
thalamic midline nucleus reuniens (RE) is a crucial link in the communication between …

N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently
characterized protein quality control system that positively selects properly folded …

The mammalian brain comprises two structurally and functionally distinct compartments: the
gray matter (GM) and the white matter (WM). In humans, the WM constitutes approximately …

Endoplasmic reticulum-based N ɛ-lysine acetylation serves as an important protein quality
control system for the secretory pathway. Dysfunctional endoplasmic reticulum-based …

Purpose The clinical diagnosis and classification of Alexander disease (AxD) relies in part
on qualitative neuroimaging biomarkers; however, these biomarkers fail to distinguish and …

Schizophrenia is a neuropsychiatric disorder characterized by multifactorial etiology
involving complex interactions among genetic and environmental factors.“Multiple-hit” …

Genome editing in pigs has been made efficient, practical, and economically viable by the
CRISPR/Cas9 platform, representing a promising new era in translational modeling of …

Background Diffusion tensor imaging suggests that white matter alterations are already
evident in first episode psychosis patients (FEP) and may become more prominent as the …

Autism spectrum disorder (ASD) is a highly prevalent, heterogenous neurodevelopmental
disorder. Neuroimaging methods such as functional, structural, and diffusion MRI have been …