The field of multi-omics has witnessed unprecedented growth, converging multiple scientific
disciplines and technological advances. This surge is evidenced by a more than doubling in …

Several unmet needs have been identified in allergic rhinitis: identification of the time of
onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification …

Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …

Many common diseases, such as asthma, diabetes or obesity, involve altered interactions
between thousands of genes. High-throughput techniques (omics) allow identification of …

Dendritic cells (DC) play unique and diverse roles in the tumor occurrence, development,
progression and response to therapy. First of all, DC can actively uptake tumor-associated …

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been
discovered as a potent factor implicated in various inflammation-associated diseases …

The human genome codes for 21 S100 protein family members, which exhibit cell-and
tissue-specific expression patterns. Despite sharing a high degree of sequence and …

Background Genomic medicine has paved the way for identifying biomarkers and
therapeutically actionable targets for complex diseases, but is complicated by the …

Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical
and immunological phenotypes. By applying a multiomics approach to a large group of RAG …

Early regulators of disease may increase understanding of disease mechanisms and serve
as markers for presymptomatic diagnosis and treatment. However, early regulators are …