Injured peripheral nerves but not central nerves have the capacity to regenerate and
reinnervate their target organs. After the two most severe peripheral nerve injuries of six …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

The therapy of neural nerve injuries that involve the disruption of axonal pathways or axonal
tracts has taken a new dimension with the development of tissue engineering techniques …

Neurons of the peripheral nervous system retain the intrinsic capability of regenerate their
axons after injury, by triggering a complex activation response. This genetic switch is …

Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

The efficiency of nerve guide conduits (NGCs) in repairing peripheral nerve injury is not high
enough yet to be a substitute for autografts and is still insufficient for clinical use. To improve …

Peripheral nerve injuries commonly occur due to trauma, like a traffic accident. Peripheral
nerves get severed, causing motor neuron death and potential muscle atrophy. The current …

Neurological disorders are one of the leading causes of morbidity and mortality worldwide,
and their therapeutic options remain limited. Recent animal and clinical studies have shown …

Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent
of myelination, and contribute to damage in prediabetic peripheral neuropathy (PN). Here …