Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

Voltage-gated Ca 2+ channels couple membrane depolarization to Ca 2+-dependent
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …

The vaccinia-related kinases (VRKs) comprise a branch of the casein kinase family whose
members are characterized by homology to the vaccinia virus B1 kinase. The VRK …

Barrier‐to‐autointegration factor (BAF) is an essential, highly conserved, metazoan protein.
BAF interacts with LEM (L AP2, e merin, M AN1) domain‐carrying proteins of the inner …

About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases,
but the structural details of kinase inactivation have remained unclear. We present the first …

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

An increasing number of transcription factors have been shown to elicit oncogenic and
tumor suppressor activities, depending on the tissue and cell context. Activating transcription …

Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational
modification of the N-terminal tail of histone proteins, particularly by phosphorylation by …

In eukaryotic cells, relaxed interphase chromatin undergoes pronounced changes resulting
in formation of highly condensed mitotic chromosomes. Moreover, chromatin condensation …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …