Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious
diseases in many tropical regions, including Nigeria, a West African country where …

Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

2H-Indazoles are one class of the most important nitrogen-containing heterocyclic
compounds. The 2H-indazole motif is widely present in bioactive natural products and drug …

A platform approach for the direct synthesis of 3-substituted 2H-indazole derivatives has
been developed using a Ag (I)/Na2S2O8 system. This regioselective alkylation/acylation …

New antimalarial treatments are now urgently required, following the emergence of
resistance to the most used drugs. Natural products contribute greatly to the therapeutic …

Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

A visible-light-promoted regioselective C (sp2)–H/C (sp3)–H cross-dehydrogenative
coupling between 2 H-indazoles and ethers has been achieved using a catalytic amount of …

Ethnopharmacological Relevance. Cryptolepis sanguinolenta is a scrambling thin‐stemmed
shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria …

New treatments for malaria are urgently needed due to the increasing problem of drug-
resistance in malaria parasites. The long-established use of quinine and the more recent …

Ethnopharmacological relevance Malaria is the most prevalent parasitic disease and the
foremost cause of morbidity and mortality in the Democratic Republic of Congo. For the …