Worldwide, the total incidence of cutaneous melanoma is higher in men than in women, with
some differences related to ethnicity and age and, above all, sex and gender. Differences …

Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in
older adults. Although the exact mechanisms underlying sarcopenia are not fully …

MicroRNAs (miRNA) are small-non coding RNAs endowed with great regulatory power, thus
playing key roles not only in almost all physiological pathways, but also in the pathogenesis …

Mitochondria are intracellular organelles with two distinct membranes, known as an outer
mitochondrial membrane and inner cell membrane. Originally, mitochondria have been …

Background Cellular sex has rarely been considered as a biological variable in preclinical
research, even when the pathogenesis of diseases with predictable sex differences is …

OBJECTIVES: Preclinical studies provide an opportunity to evaluate the relationship
between sex and sepsis, and investigate underlying mechanisms in a controlled …

Sex differences in human survival have been extensively investigated in many studies that
have in part uncovered the biological determinants that promote a longer life in females with …

Pulmonary hypertension (PH) is a condition characterised by an abnormal elevation of
pulmonary artery pressure caused by an increased pulmonary vascular resistance …

Simple Summary Autophagy is a complex cell process that allow the cell to survive in
unfavorable conditions, eg, in the lack of nutritional elements coming from the environment …

Purpose Myocardial ischemia-reperfusion injury (MIRI) is a common pathophysiological
process after occlusion of the blood vessels to restore blood supply. Apoptosis is one of the …