Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Lentiviral vectors for T cell engineering: clinical applications, bioprocessing and future perspectives

RP Labbé, S Vessillier, QA Rafiq - Viruses, 2021 - mdpi.com
Lentiviral vectors have played a critical role in the emergence of gene-modified cell
therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel …

Gene therapy potential for genetic disorders of surfactant dysfunction

AL Cooney, JA Wambach, PL Sinn… - Frontiers in genome …, 2022 - frontiersin.org
Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface
tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in …

Lentiviral vectors for ocular gene therapy

Y Arsenijevic, A Berger, F Udry, C Kostic - Pharmaceutics, 2022 - mdpi.com
This review offers the basics of lentiviral vector technologies, their advantages and pitfalls,
and an overview of their use in the field of ophthalmology. First, the description of the global …

Packaging cells for lentiviral vectors generated using the cumate and coumermycin gene induction systems and nanowell single-cell cloning

S Broussau, V Lytvyn, M Simoneau, C Guilbault… - … Therapy Methods & …, 2023 - cell.com
Lentiviral vectors (LVs) are important for cell therapy because of their capacity to stably
modify the genome after integration. This study describes a novel and relatively simple …

Use of lentiviral vectors in vaccination

MW Ku, P Charneau, L Majlessi - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Lentiviral vectors have emerged as powerful vectors for vaccination, due to their
high efficiency to transduce dendritic cells and to induce long-lasting humoral immunity …

Gene Therapy and kidney diseases

N Tavakolidakhrabadi, WY Ding, MA Saleem… - … Therapy Methods & …, 2024 - cell.com
Chronic kidney disease (CKD) poses a significant global health challenge, projected to
become one of the leading causes of death by 2040. Current treatments primarily manage …

Optimizing and developing a scalable, chemically defined, animal component-free lentiviral vector production process in a fixed-bed bioreactor

CR Fiol, ML Collignon, J Welsh, QA Rafiq - Molecular Therapy-Methods & …, 2023 - cell.com
Lentiviral vectors (LVVs) play a critical role in gene delivery for ex vivo gene-modified cell
therapies. However, the lack of scalable LVV production methods and the high cost …

Affinity Purification and Molecular Characterization of Angiotensin-Converting Enzyme (ACE)-Inhibitory Peptides from Takifugu flavidus

Y Su, S Chen, S Liu, Y Wang, X Chen, M Xu, S Cai… - Marine Drugs, 2023 - mdpi.com
An affinity chromatography filler of CNBr-activated Sepharose 4B-immobilized ACE was
used to purify ACE-inhibitory peptides from Takifugu flavidus protein hydrolysate (< 1 kDa) …

[HTML][HTML] In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet?

N Echeverría, V Comas, F Aldunate… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is responsible for no less than 71 million people chronically infected
and is one of the most frequent indications for liver transplantation worldwide. Despite direct …