TGF‐β signalling and liver disease

I Fabregat, J Moreno‐Càceres, A Sánchez… - The FEBS …, 2016 - Wiley Online Library
The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

[HTML][HTML] Epigenetics in hepatocellular carcinoma: an update and future therapy perspectives

L Ma, MS Chua, O Andrisani, S So - World Journal of …, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), the predominant form of adult liver malignancies, is a
global health concern. Its dismal prognosis has prompted recent significant advances in the …

Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation

O Alder, R Cullum, S Lee, AC Kan, W Wei, Y Yi… - Cell reports, 2014 - cell.com
Cell fate acquisition is heavily influenced by direct interactions between master regulators
and tissue-specific enhancers. However, it remains unclear how lineage-specifying …

Regulation of microRNAs and their role in liver development, regeneration and disease

ML Finch, JU Marquardt, GC Yeoh, BA Callus - The international journal of …, 2014 - Elsevier
Since their discovery more than a decade ago microRNAs have been demonstrated to have
profound effects on almost every aspect of biology. Numerous studies in recent years have …

Micro RNA s: the fine modulators of liver development and function

Y Chen, CM Verfaillie - Liver International, 2014 - Wiley Online Library
Micro RNA s are a class of small non‐coding RNA s involved in the transcriptional and post‐
transcriptional regulation of gene expression. The function of mi RNA s in liver disease …

[HTML][HTML] Oncogenic role of microRNA‑20a in human uveal melanoma

J Zhou, J Jiang, S Wang, X Xia - Molecular Medicine …, 2016 - spandidos-publications.com
As a member of the microRNA (miR)-17-92 cluster, miR‑20a has been indicated to be
involved in the regulation of the proliferation and invasion of various cancer cells. Previous …

DECODE: an integrated differential co-expression and differential expression analysis of gene expression data

TWH Lui, NBY Tsui, LWC Chan, CSC Wong, PMF Siu… - BMC …, 2015 - Springer
Background Both differential expression (DE) and differential co-expression (DC) analyses
are appreciated as useful tools in understanding gene regulation related to complex …

Pten regulates retinal amacrine cell number by modulating Akt, Tgfβ, and Erk signaling

N Tachibana, R Cantrup, R Dixit, Y Touahri… - Journal of …, 2016 - Soc Neuroscience
All tissues are genetically programmed to acquire an optimal size that is defined by total cell
number and individual cellular dimensions. The retina contains stereotyped proportions of …

Single-cell non-coding RNA in embryonic development

Q Fu, CJ Liu, ZS Zhai, X Zhang, T Qin… - Single Cell …, 2018 - Springer
Non-coding RNAs (ncRNAs) have significant regulatory functions on the regulation of gene
expression of various life activities after transcription, even though they do not encode …

Research trends in the efficacy of stem cell therapy for hepatic diseases based on MicroRNA profiling

M Kweon, JY Kim, JH Jun, GJ Kim - International journal of molecular …, 2020 - mdpi.com
Liver diseases, despite the organ's high regenerative capacity, are caused by several
environmental factors and persistent injuries. Their optimal treatment is a liver …