Potential and therapeutic roles of diosmin in human diseases

E Huwait, M Mobashir - Biomedicines, 2022 - mdpi.com
Because of their medicinal characteristics, effectiveness, and importance, plant-derived
flavonoids have been a possible subject of research for many years, particularly in the last …

[HTML][HTML] Pharmacogenomics: a genetic approach to drug development and therapy

R Qahwaji, I Ashankyty, NS Sannan, MS Hazzazi… - Pharmaceuticals, 2024 - mdpi.com
The majority of the well-known pharmacogenomics research used in the medical sciences
contributes to our understanding of medication interactions. It has a significant impact on …

Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation

B Khan, R Qahwaji, MS Alfaifi, T Athar, A Khan… - Scientific Reports, 2024 - nature.com
Breast cancer is caused by aberrant breast cells that proliferate and develop into tumors.
Tumors have the potential to spread throughout the body and become lethal if ignored …

Synthesis of silver nano particles using myricetin and the in-vitro assessment of anti-colorectal cancer activity: In-silico integration

ST Anwer, M Mobashir, OI Fantoukh, B Khan… - International Journal of …, 2022 - mdpi.com
The creation of novel anticancer treatments for a variety of human illnesses, including
different malignancies and dangerous microbes, also potentially depends on nanoparticles …

NF-kB in signaling patterns and its temporal dynamics encode/decode human diseases

S Almowallad, LS Alqahtani, M Mobashir - Life, 2022 - mdpi.com
Defects in signaling pathways are the root cause of many disorders. These malformations
come in a wide variety of types, and their causes are also very diverse. Some of these flaws …

Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer

HI Khouja, IM Ashankyty, LH Bajrai, PKP Kumar… - Scientific Reports, 2022 - nature.com
Cancer is among the highly complex disease and renal cell carcinoma is the sixth-leading
cause of cancer death. In order to understand complex diseases such as cancer, diabetes …

An approach for systems-level understanding of prostate cancer from high-throughput data integration to pathway modeling and simulation

M Mobashir, SP Turunen, MA Izhari, IM Ashankyty… - Cells, 2022 - mdpi.com
To understand complex diseases, high-throughput data are generated at large and multiple
levels. However, extracting meaningful information from large datasets for comprehensive …

A network-guided approach to discover phytochemical-based anticancer therapy: Targeting MARK4 for hepatocellular carcinoma

S Ahmed, M Mobashir, LA Al-Keridis… - Frontiers in …, 2022 - frontiersin.org
MAP/microtubule affinity-regulating kinase 4 (MARK4) is associated with various biological
functions, including neuronal migration, cell polarity, microtubule dynamics, apoptosis, and …

Global gene expression and docking profiling of COVID-19 infection

A Jabeen, N Ahmad, K Raza - Frontiers in genetics, 2022 - frontiersin.org
Coronavirus is an enclosed positive-sense RNA virus with club-like spikes protruding from
its surface that causes acute respiratory infections in humans. Because it is considered a …

Coronavirus disease 2019, diabetes, and inflammation: a systemic review

M Ferguson, J Vel, V Phan, R Ali, L Mabe… - Metabolic Syndrome …, 2023 - liebertpub.com
People with cardiometabolic diseases [namely type 2 diabetes (T2D), obesity, or metabolic
syndrome] are more susceptible to coronavirus disease 2019 (COVID-19) infection and …