Tumour-targeting bacteria engineered to fight cancer

S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018 - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

Bacteria-cancer interactions: bacteria-based cancer therapy

MTQ Duong, Y Qin, SH You, JJ Min - Experimental & molecular …, 2019 - nature.com
Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

M Sedighi, A Zahedi Bialvaei, MR Hamblin… - Cancer …, 2019 - Wiley Online Library
Successful treatment of cancer remains a challenge, due to the unique pathophysiology of
solid tumors, and the predictable emergence of resistance. Traditional methods for cancer …

Bioengineered and biohybrid bacteria-based systems for drug delivery

Z Hosseinidoust, B Mostaghaci, O Yasa… - Advanced drug delivery …, 2016 - Elsevier
The use of bacterial cells as agents of medical therapy has a long history. Research that was
ignited over a century ago with the accidental infection of cancer patients has matured into a …

Engineering the perfect (bacterial) cancer therapy

NS Forbes - Nature Reviews Cancer, 2010 - nature.com
Bacterial therapies possess many unique mechanisms for treating cancer that are
unachievable with standard methods. Bacteria can specifically target tumours, actively …

Progress of engineered bacteria for tumor therapy

JX Fan, MT Niu, YT Qin, YX Sun, XZ Zhang - Advanced Drug Delivery …, 2022 - Elsevier
Recently, with the rapid development of bioengineering technology and nanotechnology,
natural bacteria were modified to change their physiological activities and therapeutic …

Bacterial-based cancer therapy (BBCT): recent advances, current challenges, and future prospects for cancer immunotherapy

KH Gupta, C Nowicki, EF Giurini, AL Marzo, A Zloza - Vaccines, 2021 - mdpi.com
Currently approximately 10 million people die each year due to cancer, and cancer is the
cause of every sixth death worldwide. Tremendous efforts and progress have been made …

Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

[HTML][HTML] Bacteria and bacterial derivatives as delivery carriers for immunotherapy

SR Kang, DH Nguyen, SW Yoo, JJ Min - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Bacteria in cancer therapy: renaissance of an old concept

S Felgner, D Kocijancic, M Frahm… - International journal of …, 2016 - Wiley Online Library
The rising incidence of cancer cases worldwide generates an urgent need of novel
treatment options. Applying bacteria may represent a valuable therapeutic variant that is …