Peptidomimetics represent an important field in chemistry, pharmacology and material
science as they circumvent the limitations of traditional peptides used in therapy. Self …

Azapeptides are peptide analogs in which one or more of the amino residues is replaced by
a semicarbazide. This substitution of a nitrogen for the α-carbon center results in …

Carbon quantum dots (CQDs) were synthesized in this study by hydrothermally treating cow
milk. The procedure is simple, non-hazardous to the environment, and does not necessitate …

Functionalized proline residues have diverse applications. Herein we describe a practical
approach, proline editing, for the synthesis of peptides with stereospecifically modified …

Conspectus Mimicry of bioactive conformations is critical for peptide-based medicinal
chemistry because such peptidomimetics may augment stability, enhance affinity, and …

The shortcomings of native peptides as pharmaceuticals have been long known: short
duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal …

Peptide‐based therapeutics have grown in importance over the last few decades.
Furthermore, peptides have been extensively used as lead compounds in the drug …

Aza-peptides, peptide analogues in which the α-carbon of one or more of the amino acid
residues is replaced with a nitrogen atom, exhibit a propensity for adopting β-turn …

Using the example of cathepsin K, we demonstrate the design of highly potent and selective
azadipeptide nitrile inhibitors. A systematic scan with respect to P2 and P3 substituents was …

Submonomer synthesis of aza-peptides featuring regioselective alkylation of peptide-bound
aza-Gly residues provided ten aza-analogues of the Growth Hormone Releasing Peptide-6 …