The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Obesity increases a number of cardiovascular disease (CVD) risk factors, but patients with
many types of CVD may have a better prognosis if classified as overweight or obese, a …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Inflammation has been recognized as a major pathophysiological contributor to the entire
spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with …

Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …

Aims Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac
inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which …

Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …

The escalating prevalence of obesity has been linked to substantial increases in both
metabolic and cardiovascular disease. Nevertheless, the direct effects of obesity on …

Abstract Background/Aims. Early inflammatory responses after myocardial infarction (MI) are
likely to increase myocardial fibrosis and subsequent cardiac remodeling. MCC950, a …