N-heterocycles are important, not only because of their abundance, but above all because of
their chemical, biological and technical significance. They play an important role in …

Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …

Thiazolidinone is a biologically important five‐membered heterocyclic ring having almost all
types of biological activities. This review covers various types of thiazolidinones, such as 2 …

Introduction Several viral infections cause life-threatening consequences in humans, making
them the most serious public health concerns. Despite the fact that several antiviral …

With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …

Over recent years, many outbreaks caused by (re) emerging RNA viruses have been
reported worldwide, including life-threatening Flaviviruses, such as Dengue (DENV) and …

1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

The discovery and optimization of non-nucleoside dengue viral RNA-dependent-RNA
polymerase (RdRp) inhibitors are described. An X-ray-based fragment screen of Novartis' …

Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological
consequences for infected infants and adults, there are still no approved drugs to treat ZIKV …

Aim: To synthesize a series of new thiazolidinone–pyrazole hybrids (5a–o) and assess their
anticancer (in vitro and in vivo) and antimicrobial activities. Results: The compounds 5h …