Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …

Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionarily conserved
sensor of cellular energy status and has been reported to be involved in chronic …

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

Low-grade inflammation and insulin resistance are among the clinical features of obesity
that are thought to promote the progressive onset of type 2 diabetes. However, the …

Significance: This review highlights the many intracellular processes generating reactive
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …

Mitochondrial dysfunction has been implicated as a one of the major factors linked to the
development of painful diabetic neuropathy (DN). Several studies have demonstrated that …

As a major late complication of diabetes, diabetic peripheral neuropathy (DPN) is the
primary reason for amputation. Nevertheless, there are no wonder drugs available …

Adenosine 5′-monophosphate activated protein kinase (AMPK) is a key enzymatic protein
involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine …

Abstract Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress
mechanism and has anti-inflammatory potential in various inflammatory conditions …