Personalized mid-course fdg-pet based adaptive treatment planning for non-small cell lung cancer using machine learning and optimization
Objective. Traditional radiotherapy (RT) treatment planning of non-small cell lung cancer
(NSCLC) relies on population-wide estimates of organ tolerance to minimize excess toxicity …
(NSCLC) relies on population-wide estimates of organ tolerance to minimize excess toxicity …
Imputing radiobiological parameters of the linear-quadratic dose-response model from a radiotherapy fractionation plan
A Ghate - Physics in Medicine & Biology, 2020 - iopscience.iop.org
The objective in cancer radiotherapy is to maximize tumor-kill while limiting toxic effects of
radiation dose on nearby organs-at-risk (OAR). Given a fixed number of treatment sessions …
radiation dose on nearby organs-at-risk (OAR). Given a fixed number of treatment sessions …
Value of intermediate imaging in adaptive robust radiotherapy planning to manage radioresistance
In radiotherapy, uncertainties in tumor radioresistance and its progression can degrade the
efficacy of deterministic treatments. While a robust methodology can overcome this, it often …
efficacy of deterministic treatments. While a robust methodology can overcome this, it often …
[图书][B] Optimal Fractionation in Radiotherapy
A Ghate - 2023 - books.google.com
This monograph provides a mathematically rigorous overview of optimal fractionation in
cancer radiotherapy, which seeks to address the fundamental tradeoff of maximizing tumor …
cancer radiotherapy, which seeks to address the fundamental tradeoff of maximizing tumor …
Adaptive treatment-length optimization in spatiobiologically integrated radiotherapy
Recent theoretical research on spatiobiologically integrated radiotherapy has focused on
optimization models that adapt fluence-maps to the evolution of tumor state, for example, cell …
optimization models that adapt fluence-maps to the evolution of tumor state, for example, cell …
Spatiotemporal radiotherapy planning using a global optimization approach
This paper aims at quantifying the extent of potential therapeutic gain, measured using
biologically effective dose (BED), that can be achieved by altering the radiation dose …
biologically effective dose (BED), that can be achieved by altering the radiation dose …
Response-guided dosing in cancer radiotherapy
A Ghate - Tutorials in Operations Research: Emerging …, 2021 - pubsonline.informs.org
The goal in radiotherapy for cancer is to maximize tumor-kill while limiting toxic effects on
nearby healthy anatomies. This is attempted via spatial localization of the radiation dose …
nearby healthy anatomies. This is attempted via spatial localization of the radiation dose …
A theoretical framework for learning tumor dose-response uncertainty in individualized spatiobiologically integrated radiotherapy
A Ajdari, F Saberian, A Ghate - INFORMS Journal on …, 2020 - pubsonline.informs.org
Recent theoretical research has employed the linear-quadratic model of dose-response in
stochastic control formulations for spatiobiologically integrated radiotherapy. The goal is to …
stochastic control formulations for spatiobiologically integrated radiotherapy. The goal is to …
Scalable Optimization Methods for Incorporating Spatiotemporal Fractionation into Intensity-Modulated Radiotherapy Planning
It has been recently shown that an additional therapeutic gain may be achieved if a
radiotherapy plan is altered over the treatment course using a new treatment paradigm …
radiotherapy plan is altered over the treatment course using a new treatment paradigm …
Convex and robust optimization methods for modality selection in external beam radiotherapy
S Nourollahi - 2018 - digital.lib.washington.edu
The goal in external beam radiotherapy (EBRT) for cancer is to maximize damage to the
tumor while limiting toxic effects of radiation dose on the organs-at-risk (OAR). EBRT can be …
tumor while limiting toxic effects of radiation dose on the organs-at-risk (OAR). EBRT can be …