[HTML][HTML] INVITED REVIEW: Ketone biology: the shifting paradigm of ketones and ketosis in the dairy cow.

JE Rico, MA Barrientos-Blanco - Journal of Dairy Science, 2024 - Elsevier
Ketosis is currently regarded as a major metabolic disorder of dairy cows, reflective of the
animal's efforts to adapt to energy deficit while transitioning into lactation. Currently viewed …

[HTML][HTML] Lipolysis inhibition as a treatment of clinical ketosis in dairy cows: Effects on adipose tissue metabolic and immune responses

M Chirivi, D Cortes, CJ Rendon, GA Contreras - Journal of Dairy Science, 2024 - Elsevier
Dairy cows with clinical ketosis (CK) exhibit excessive adipose tissue (AT) lipolysis and
systemic inflammation. Lipolysis in cows can be induced by the canonical (hormonally …

Endotoxin-induced alterations of adipose tissue function: a pathway to bovine metabolic stress

M Chirivi, GA Contreras - Journal of Animal Science and Biotechnology, 2024 - Springer
During the periparturient period, dairy cows exhibit negative energy balance due to limited
appetite and increased energy requirements for lactogenesis. The delicate equilibrium …

[HTML][HTML] Assessing the Usefulness of Interleukin-8 as a Biomarker of Inflammation and Metabolic Dysregulation in Dairy Cows

K Puppel, J Slósarz, P Solarczyk… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The study aimed to evaluate interleukin-8 (IL-8) as a biomarker for udder inflammation in
dairy cows and to explore its associations with various metabolic parameters indicative of …

Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats

Y Wang, X Chen, SA Huws, G Xu, J Li, J Ren, J Xu… - Microbiome, 2024 - Springer
Background Liver damage from nonalcoholic steatohepatitis (NASH) presents a significant
challenge to the health and productivity of ruminants. However, the regulatory mechanisms …

Treatment of cows with liver pathology using a liposomal drug based on extract from the fruits of Silybum marianum

V Vlizlo, O Prystupa, L Slivinska, B Gutyj… - Regulatory …, 2024 - medicine.dp.ua
After labor, dairy cows are often diagnosed with fatty liver disease. The objective of our study
was to identify the efficacy of a liposomal drug based on extract from seeds of Silybum …

[HTML][HTML] International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation: lights and shadows

E Trevisi, L Cattaneo, F Piccioli-Cappelli… - Journal of Dairy …, 2025 - Elsevier
The mismatch between the nutrient intake from the diet and the output by the mammary
gland causes a negative energy balance in transition dairy cows, that, if excessive, can …

[HTML][HTML] Associations of Body Condition Score, Body Condition Score Change, and Hyperketonemia with Mastitis, Reproduction, and Milk Production

KC Krogstad, BJ Bradford - Journal of Dairy Science, 2024 - Elsevier
Body condition score (BCS) and hyperketonemia (HYK) have been associated with
diseases, fertility, and culling but data are contradictory about their association with …

Multi-Omics Reveals Disrupted Immunometabolic Homeostasis and Oxidative Stress in Adipose Tissue of Dairy Cows with Subclinical Ketosis: A Sphingolipid-Centric …

H Zhao, L Li, J Tan, Y Wang, A Zhang, Y Zhao, L Jiang - Antioxidants, 2024 - mdpi.com
Ketosis, especially its subclinical form, is frequently observed in high-yielding dairy cows
and is linked to various diseases during the transition period. Although adipose tissue plays …

Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway

J Chang, Z Wang, Y Hao, Y Song, C Xia - Animals, 2024 - mdpi.com
Simple Summary Clinical ketosis is a dangerous disease in the dairy industry, as it affects
milk production in cows. We imply that calmodulin is abundantly expressed in adipocytes …