Glioblastoma is the most aggressive form of malignant brain tumor. Standard treatment
protocols and traditional immunotherapy are poorly effective as they do not significantly …

Tumor microenvironment (TME) is the cornerstone of the occurrence, development, invasion
and diffusion of the malignant central nerve system (CNS) tumor, glioma. As the largest …

Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both
humans and mice and their presence is linked to poor clinical outcomes for cancer patients …

Objectives Circadian rhythm controls complicated physiological activities in organisms.
Circadian clock genes have been related to tumour progression, but its role in glioma is …

Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies …

Liquid biopsy allows for the quick and noninvasive detection of tumor-associated
components. Various liquid biopsy components, which include circulating tumor cells, tumor …

Myeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell
population among immune cells within the tumour microenvironment (TME) that support …

Background Glioblastoma, or glioblastoma multiforme (GBM), remains a fatal cancer type
despite the remarkable progress in understanding the genesis and propagation of the tumor …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Glioma is the most common intracranial malignant tumor, and the current main standard
treatment option is a combination of tumor surgical resection, chemotherapy and …