The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

Sortases are a class of bacterial enzymes that possess transpeptidase activity. It is their
ability to site‐specifically break a peptide bond and then reform a new bond with an …

Gram-positive bacteria use sortase cysteine transpeptidase enzymes to covalently attach
proteins to their cell wall and to assemble pili. In pathogenic bacteria sortases are potential …

The gram-positive bacterium Staphylococcus aureus is a frequent component of the human
microbial flora that can turn into a dangerous pathogen. As such, this organism is capable of …

The cell wall envelope of staphylococci and other Gram-positive pathogens is coated with
surface proteins that interact with human host tissues. Surface proteins of Staphylococcus …

A new enzymatic protein ligation tool, sortase, has recently emerged from Gram‐positive
bacteria. This article outlines the technique, sortase‐mediated ligation, and its applications …

The rise in antibiotic-resistant bacteria is a major concern, in particular because it includes
many different species of pathogenic microbes. These “superbugs” are further characterized …

Surface proteins are critical in determining the identifying characteristics of individual
bacteria and their interaction with the environment. Because the structure of the cell surface …

In Gram-positive bacteria, sortase enzymes assemble surface proteins and pili in the cell
wall envelope. Sortases catalyze a transpeptidation reaction that joins a highly conserved …

The covalent anchoring of surface proteins to the cell wall envelope of Gram-positive
bacteria occurs by a universal mechanism requiring sortases, extracellular transpeptidases …