Pain-resolving immune mechanisms in neuropathic pain

NT Fiore, SR Debs, JP Hayes, SS Duffy… - Nature Reviews …, 2023 - nature.com
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain

G Chen, YQ Zhang, YJ Qadri, CN Serhan, RR Ji - Neuron, 2018 - cell.com
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet… - Pharmacological …, 2018 - Elsevier
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Emerging targets in neuroinflammation-driven chronic pain

RR Ji, ZZ Xu, YJ Gao - Nature reviews Drug discovery, 2014 - nature.com
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Glia and pain: is chronic pain a gliopathy?

RR Ji, T Berta, M Nedergaard - Pain®, 2013 - Elsevier
Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Lipid mediators in the resolution of inflammation

CN Serhan, N Chiang, J Dalli… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

MK Ahmmed, F Ahmmed, H Tian… - … reviews in food …, 2020 - Wiley Online Library
For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

Neuroinflammation and the generation of neuropathic pain

A Ellis, DLH Bennett - British journal of anaesthesia, 2013 - academic.oup.com
Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

CN Serhan, N Chiang, J Dalli - Molecular aspects of medicine, 2018 - Elsevier
While protective, the acute inflammatory response when uncontrolled can lead to further
tissue damage and chronic inflammation that is now widely recognized to play important …

Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial

CE Ramsden, D Zamora, KR Faurot, B MacIntosh… - bmj, 2021 - bmj.com
Objective To determine whether dietary interventions that increase n-3 fatty acids with and
without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in …