As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-
cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical …

Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)–DQA1* 01:
02/DQB1* 06: 02 (DQ0602), is characterized by excessive daytime sleepiness, cataplexy …

T cell receptors (TCR) containing Vβ20-1 have been implicated in a wide range of T cell
mediated disease and allergic reactions, making it a target for understanding these …

αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …

Fluorochrome-conjugated peptide–MHC (pMHC) multimers are commonly used in
combination with flow cytometry for direct ex vivo visualization and characterization of Ag …

MHC anchor residue‐modified “heteroclitic” peptides have been used in many cancer
vaccine trials and often induce greater immune responses than the wild‐type peptide. The …

T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major
histocompatibility complexes (pMHCs). The nature of the interaction between these two …