Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …

Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-
19) and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Background Extracorporeal membrane oxygenation (ECMO) has been used extensively for
coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) …

Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting …

While studies have elucidated many pathophysiological elements of COVID-19, little is
known about immunological changes during COVID-19 resolution. We analyzed immune …

Background Imatinib reduced 90-day mortality in hospitalised coronavirus disease 2019
(COVID-19) patients in a recent clinical trial, but the biological effects that cause improved …