In silico toxicology is an emerging field. It gains increasing importance as research is aiming
to decrease the use of animal experiments as suggested in the 3R principles by Russell and …

Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …

Chemical pollution can threaten biodiversity at different levels, from genetically diverse
populations (genetic diversity) to different species (species diversity) and ecosystem …

The EPA developed the Adverse Outcome Pathway Database (AOP-DB) to better
characterize adverse outcomes of toxicological interest that are relevant to human health …

Growing numbers of synthetic chemicals have potential endocrine-disrupting effects and
cause potential ecological and health risks. However, the primary toxicity pathways and …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org) is a public
resource that manually curates the scientific literature to provide content that illuminates the …

Numerous chemical compounds are distributed around the world and may affect the
homeostasis of the endocrine system by disrupting the normal functions of hormone …

Environmental health studies relate how exposures (eg, chemicals) affect human health and
disease; however, in most cases, the molecular and biological mechanisms connecting an …

Introduction: The AOP-Wiki is the main platform for the development and storage of adverse
outcome pathways (AOPs). These AOPs describe mechanistic information about …