Cardiovascular complications of immune checkpoint inhibitors for cancer

F Thuny, J Naidoo, TG Neilan - European heart journal, 2022 - academic.oup.com
Over the last decade or so, there has been a paradigm shift in the oncologic care of patients
with a range of solid tumour and haematologic malignancies, away from traditional cytotoxic …

Predictive biomarkers for checkpoint inhibitor immune-related adverse events

I Les, M Martinez, I Perez-Francisco, M Cabero… - Cancers, 2023 - mdpi.com
Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment
of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients …

Mechanisms driving immune-related adverse events in cancer patients treated with immune checkpoint inhibitors

DJ Lee, HJ Lee, JR Farmer, KL Reynolds - Current Cardiology Reports, 2021 - Springer
Abstract Purpose of Review In the past decade, immune checkpoint inhibitors (ICIs) have
revolutionized the field of cancer treatment. With the continuing rise in the number of cancer …

Neutrophil-to-lymphocyte ratio an inflammatory biomarker, and prognostic marker in heart failure, cardiovascular disease and chronic inflammatory diseases: New …

A García-Escobar, S Vera-Vera, D Tébar-Márquez… - Microvascular …, 2023 - Elsevier
In the 20th century, research focused on cholesterol and lipoproteins as the key mechanism
in establishing atherosclerotic cardiovascular disease (ASCVD). Given that some studies …

[HTML][HTML] Pericardial disease in patients treated with immune checkpoint inhibitors

J Gong, ZD Drobni, A Zafar, T Quinaglia… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background There are limited data on the occurrence, associations and outcomes of
pericardial effusions and pericarditis on or after treatment with immune checkpoint inhibitors …

Neutrophil to Lymphocyte ratio as a predictor for immune-related adverse events in cancer patients treated with immune checkpoint inhibitors: a systematic review and …

W Zhang, Y Tan, Y Li, J Liu - Frontiers in Immunology, 2023 - frontiersin.org
Background The use of immune checkpoint inhibitors (ICIs) in cancer treatment has led to an
increase in immune-related adverse events (irAEs), which can cause treatment …

Peripheral blood biomarkers for early diagnosis, severity, and prognosis of checkpoint inhibitor-related pneumonitis in patients with lung cancer

X Lin, H Deng, Y Yang, J Wu, G Qiu, S Li, X Xie… - Frontiers in …, 2021 - frontiersin.org
Background Checkpoint inhibitor-related pneumonitis (CIP) is a potentially fatal immune-
related adverse event that occurs during treatment with immune checkpoint inhibitors (ICIs) …

Mediators and mechanisms of immune checkpoint inhibitor‐associated myocarditis: Insights from mouse and human

J Gong, TG Neilan, DA Zlotoff - Immunological Reviews, 2023 - Wiley Online Library
The broad application of immune checkpoint inhibitors (ICIs) has led to significant gains in
cancer outcomes. By abrogating inhibitory signals, ICIs promote T cell targeting of cancer …

[HTML][HTML] Correlations between peripheral blood biomarkers and clinical outcomes in advanced non-small cell lung cancer patients who received immunotherapy …

Y Shi, X Liu, J Liu, D Zhang, X Liu, Y Yue… - Translational Lung …, 2021 - ncbi.nlm.nih.gov
Background Peripheral blood-based biomarkers (PBB) predicting response, survival and
immune-related adverse events (irAEs) in patients with advanced non-small cell lung cancer …

Fractalkine/CX3CR1 in Dilated Cardiomyopathy: A Potential Future Target for Immunomodulatory Therapy?

V Jeyalan, D Austin, SX Loh, VK Wangsaputra… - Cells, 2023 - mdpi.com
Dilated cardiomyopathy (DCM) is a cardiac condition with structural and functional
impairment, where either the left ventricle or both ventricular chambers are enlarged …