Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a
neoplastic disorder owing to the discovery of recurrent activating MAPK (RAS-RAF-MEK …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

The histiocytoses are rare disorders characterized by the accumulation of macrophage,
dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults …

Erdheim-Chester disease (ECD) is a rare, non-Langerhans histiocytosis. Recent findings
suggest that ECD is a clonal disorder, marked by recurrent BRAF V600E mutations in> 50 …

Histiocytoses constitute a heterogeneous group of rare disorders, characterised by
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …

Histiocytoses are rare disorders of unknown origin with highly heterogeneous prognosis.
BRAFV600E gain-of-function mutations have been observed in 57% of cases of Langerhans …

Purpose Histiocytoses are rare disorders with heterogeneous prognosis. BRAFV600E
mutations have been observed in half of patients with Langerhans cell histiocytosis (LCH) …

Erdheim-Chester disease (ECD) is a rare form of non-Langerhans histiocytosis, with
noncodified therapeutic management and high mortality. No treatment has yet been shown …

Histiocytoses are disorders characterised by inflammation and the accumulation of cells
derived from the monocyte and macrophage lineages, which results in tissue damage …

Abstract Erdheim-Chester Disease (ECD) is a rare form of non Langerhans' cell
histiocytosis. Individuals affected by this disease are typically adults between their 5th and …