Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation

H Ashrafian, EH Zadeh, RH Khan - International journal of biological …, 2021 - Elsevier
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Neuronal cell death mechanisms in major neurodegenerative diseases

H Chi, HY Chang, TK Sang - International journal of molecular sciences, 2018 - mdpi.com
Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …

Neurodegenerative diseases: Regenerative mechanisms and novel therapeutic approaches

R Hussain, H Zubair, S Pursell, M Shahab - Brain sciences, 2018 - mdpi.com
Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

Tau protein modifications and interactions: their role in function and dysfunction

A Mietelska-Porowska, U Wasik, M Goras… - International journal of …, 2014 - mdpi.com
Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

C Phillips, MA Baktir, M Srivatsan… - Frontiers in cellular …, 2014 - frontiersin.org
While the relationship between increased physical activity and cognitive ability has been
conjectured for centuries, only recently have the mechanisms underlying this relationship …

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

M Baker, IR Mackenzie, SM Pickering-Brown, J Gass… - Nature, 2006 - nature.com
Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years. A large proportion of FTD patients (35–50%) have a family history …

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs

S Thakral, A Yadav, V Singh, M Kumar, P Kumar… - Ageing Research …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease

R Schliebs, T Arendt - Journal of neural transmission, 2006 - Springer
Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

L Trillo, D Das, W Hsieh, B Medina… - Neuroscience & …, 2013 - Elsevier
Extensive neuropathological studies have established a compelling link between
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …

Functions and mechanisms of retrograde neurotrophin signalling

LS Zweifel, R Kuruvilla, DD Ginty - Nature reviews neuroscience, 2005 - nature.com
Neuronal connections are established and refined through a series of developmental
programs that involve axon and dendrite specification, process growth, target innervation …