3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Nonclinical testing has served as a foundation for evaluating potential risks and
effectiveness of investigational new drugs in humans. However, the current two‐dimensional …
effectiveness of investigational new drugs in humans. However, the current two‐dimensional …
Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance
MJ Zamek‐Gliszczynski, ME Taub… - Clinical …, 2018 - Wiley Online Library
This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …
recommendations on transporters that are important in drug development following the 3rd …
The role of uptake and efflux transporters in the disposition of glucuronide and sulfate conjugates
E Järvinen, F Deng, W Kiander, A Sinokki… - Frontiers in …, 2022 - frontiersin.org
Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …
OAT, OATP, and MRP drug transporters and the remote sensing and signaling theory
SK Nigam, JC Granados - Annual review of pharmacology and …, 2023 - annualreviews.org
The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
[HTML][HTML] Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development
Y Lai, X Chu, L Di, W Gao, Y Guo, X Liu, C Lu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
Application of targeted mass spectrometry in bottom-up proteomics for systems biology research
NP Manes, A Nita-Lazar - Journal of proteomics, 2018 - Elsevier
The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
A comprehensive analysis of ontogeny of renal drug transporters: mRNA analyses, quantitative proteomics, and localization
KWK Cheung, BD van Groen, E Spaans… - Clinical …, 2019 - Wiley Online Library
Human renal membrane transporters play key roles in the disposition of renally cleared
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …
The role of the kidney in drug elimination: transport, metabolism, and the impact of kidney disease on drug clearance
JO Miners, X Yang, KM Knights… - Clinical Pharmacology & …, 2017 - Wiley Online Library
Recent advances in the identification and characterization of renal drug transporters and
drug‐metabolizing enzymes has led to greater understanding of their roles in drug and …
drug‐metabolizing enzymes has led to greater understanding of their roles in drug and …
Clinical relevance of hepatic and renal P‐gp/BCRP inhibition of drugs: An international transporter consortium perspective
The role of P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) in drug–drug
interactions (DDIs) and limiting drug absorption as well as restricting the brain penetration of …
interactions (DDIs) and limiting drug absorption as well as restricting the brain penetration of …