Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases, and they affect millions of people worldwide, particularly older …

The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …

Neurodegenerative diseases are critical in the healthcare system as patients suffer from
progressive diseases despite currently available drug management. Indeed, the growing …

Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various
pathogens through lysosomes as an essential way to maintain cellular homeostasis …

The failure of the proper protein turnover in the nervous system is mainly linked to a variety
of neurodegenerative disorders. Therefore, a better understanding of key protein …

Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play
an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages …

Parkinson's disease (PD) is a devastating neurodegenerative disorder predominantly
affecting the elderly, characterized by the loss of dopaminergic neurons in the substantia …

The ubiquitin–proteasome system (UPS) controls protein homeostasis to maintain cell
functionality and survival. Neurogenesis relies on proteasome function, and a defective …

Simple Summary Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis
(ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), mainly impact the central …