Immunopathogenic mechanisms of systemic autoimmune disease

M Wahren-Herlenius, T Dörner - The Lancet, 2013 - thelancet.com
Systemic lupus erythematosus, Sjögren's syndrome, and dermatomyositis are systemic
autoimmune diseases that develop after environmental triggering of genetically susceptible …

Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Vaccines for visceral leishmaniasis: A review

K Jain, NK Jain - Journal of immunological methods, 2015 - Elsevier
Visceral leishmaniasis, which is also known as Kala-Azar, is one of the most severely
neglected tropical diseases recognized by the World Health Organization (WHO). The threat …

Vaccines to prevent leishmaniasis

R Kumar, C Engwerda - Clinical & translational immunology, 2014 - Wiley Online Library
Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations
affecting people in tropical and subtropical regions of the world. Epidemiological and …

Leishmaniasis vaccine: where are we today?

L Kedzierski - Journal of global infectious diseases, 2010 - journals.lww.com
Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement
and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled …

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

M Osman, A Mistry, A Keding, R Gabe… - PLoS neglected …, 2017 - journals.plos.org
Background Visceral leishmaniasis (VL or kala azar) is the most serious form of human
leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal …

Vaccines for leishmaniasis in the fore coming 25 years

CB Palatnik-de-Sousa - Vaccine, 2008 - Elsevier
Human vaccination against leishmaniasis using live Leishmania was used in Middle East
and Russia (1941–1980). First-generation vaccines, composed by killed parasites induce …

Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model

R Gomes, C Teixeira, MJ Teixeira… - Proceedings of the …, 2008 - National Acad Sciences
Visceral leishmaniasis (VL) is a fatal disease for humans, and no vaccine is currently
available. Sand fly salivary proteins have been associated with protection against cutaneous …

From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH‐F3+ GLA‐SE

RN Coler, MS Duthie, KA Hofmeyer… - Clinical & …, 2015 - Wiley Online Library
Key antigens of Leishmania species identified in the context of host responses in
Leishmania‐exposed individuals from disease‐endemic areas were prioritized for the …

Vaccine candidates for leishmaniasis: a review

R Nagill, S Kaur - International immunopharmacology, 2011 - Elsevier
Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …