Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …

The genomic landscape of breast cancer is complex, and inter-and intra-tumour
heterogeneity are important challenges in treating the disease. In this study, we sequence …

Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …

Cancer progression in humans is difficult to infer because we do not routinely sample
patients at multiple stages of their disease. However, heterogeneous breast tumors provide …

We report that knocking down the expression of inositol polyphosphate 4-phosphatase type
II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt …

Triple negative breast cancers are defined by the absence of oestrogen, progesterone and
HER2 expression. Most triple negative cancers display distinct clinical and pathological …

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence
whole human genomes as well as cancer genomes, and the findings suggest that we may …

Background The characterization of copy number alteration patterns in breast cancer
requires high-resolution genome-wide profiling of a large panel of tumor specimens. To …

Triple-negative breast cancers (TNBCs) are a diverse and heterogeneous group of tumors
that by definition lack estrogen and progesterone receptors and amplification of the HER2 …