The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

Communication between bacteria, belonging to the same species or to different species, is
mediated through different chemical signals that are synthesized and secreted by bacteria …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

One of the important challenges in the emerging field of synthetic biology is designing
artificial networks that achieve coordinated behavior in cell communities. Here we present a …

The ErbB receptor tyrosine kinases evolved as key regulatory entities enabling the
extracellular milieu to communicate with the intracellular machinery to bring forth the …

Feedback loops have been identified in a variety of regulatory systems and organisms.
While feedback loops of the same type (negative or positive) tend to have properties in …

Systems biology seeks to develop a complete understanding of cellular mechanisms by
studying the functions of intra-and inter-cellular molecular interactions that trigger and …

The theory that the spatial organization of cell fate is orchestrated by gradients of diffusing
molecules was a major contribution to 20 th century developmental biology. Although the …

Computational models have rarely been used as tools by biologists but, when models
provide experimentally testable predictions, they can be extremely useful. The epidermal …

Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis
orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell …