Overcoming resistance to natural killer cell based immunotherapies for solid tumors
G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …
solid tumor malignancies remains poor. Different factors associated with solid tumors …
The immune privilege of cancer stem cells: a key to understanding tumor immune escape and therapy failure
C Galassi, M Musella, N Manduca, E Maccafeo… - Cells, 2021 - mdpi.com
Cancer stem cells (CSCs) are broadly considered immature, multipotent, tumorigenic cells
within the tumor mass, endowed with the ability to self-renew and escape immune control …
within the tumor mass, endowed with the ability to self-renew and escape immune control …
The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells
Despite major progress in elucidating the pathobiology of head and neck squamous cell
carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably …
carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably …
Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the …
Introduction and methods In this study we report that sequential treatment of supercharged
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …
Natural killer cell therapy: a new treatment paradigm for solid tumors
S Oh, JH Lee, KB Kwack, SW Choi - Cancers, 2019 - mdpi.com
In treatments of solid tumors, adoptive transfer of ex vivo expanded natural killer (NK) cells
has dawned as a new paradigm. Compared with cytotoxic T lymphocytes, NK cells take a …
has dawned as a new paradigm. Compared with cytotoxic T lymphocytes, NK cells take a …
Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based
therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since …
therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since …
NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis
We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
Probiotic-treated super-charged NK cells efficiently clear poorly differentiated pancreatic tumors in Hu-BLT mice
Background and Aims: We have previously demonstrated that the stage of differentiation of
tumors has profound effect on the function of NK cells, and that stem-like/poorly …
tumors has profound effect on the function of NK cells, and that stem-like/poorly …
Characterizing hepatocellular carcinoma stem markers and their corresponding susceptibility to NK-cell based immunotherapy
Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
is the fourth-leading cause of all cancer-related deaths around the world. Liver …
is the fourth-leading cause of all cancer-related deaths around the world. Liver …