A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes
M Flemr, R Malik, V Franke, J Nejepinska, R Sedlacek… - Cell, 2013 - cell.com
In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA)
and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in …
and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in …
Biochemical comparison of dsRNA degrading nucleases in four different insects
Double stranded RNAs (dsRNA) degrading nuclease is responsible for the rapid
degradation of dsRNA molecules, and thus accounts for variations in RNA interference …
degradation of dsRNA molecules, and thus accounts for variations in RNA interference …
Approaches for the discovery of small molecule ligands targeting microRNAs
DA Lorenz, AL Garner - RNA Therapeutics, 2018 - Springer
RNA is essential for life, serving as the intermediate between genomic storage and protein
function. As our knowledge of biological systems has grown, so has our understanding of …
function. As our knowledge of biological systems has grown, so has our understanding of …
Heterozygous de novo dominant negative mutation of REXO2 results in interferonopathy
Mitochondrial RNA (mtRNA) in the cytosol can trigger the innate immune sensor MDA5, and
autoinflammatory disease due to type I IFN. Here, we show that a dominant negative …
autoinflammatory disease due to type I IFN. Here, we show that a dominant negative …
4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification
LA Kiyuna, DS Candido, LRG Bechara… - European Heart …, 2023 - academic.oup.com
Abstract Background and Aims Developing novel therapies to battle the global public health
burden of heart failure remains challenging. This study investigates the underlying …
burden of heart failure remains challenging. This study investigates the underlying …
Development and implementation of an HTS-compatible assay for the discovery of selective small-molecule ligands for pre-microRNAs
DA Lorenz, S Vander Roest… - … Life Sciences R&D, 2018 - journals.sagepub.com
microRNAs (miRNAs) are small gene regulatory RNAs, and their expression has been found
to be dysregulated in a number of human diseases. To facilitate the discovery of small …
to be dysregulated in a number of human diseases. To facilitate the discovery of small …
High-throughput platform assay technology for the discovery of pre-microRNA-selective small molecule probes
DA Lorenz, JM Song, AL Garner - Bioconjugate Chemistry, 2015 - ACS Publications
MicroRNAs (miRNA) play critical roles in human development and disease. As such, the
targeting of miRNAs is considered attractive as a novel therapeutic strategy. A major …
targeting of miRNAs is considered attractive as a novel therapeutic strategy. A major …
Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles
Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream
since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA …
since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA …
Cell-based reporter system for high-throughput screening of MicroRNA pathway inhibitors and its limitations
K Brustikova, D Sedlak, J Kubikova, C Skuta… - Frontiers in …, 2018 - frontiersin.org
MicroRNAs (miRNAs) are small RNAs repressing gene expression. They contribute to many
physiological processes and pathologies. Consequently, strategies for manipulation of the …
physiological processes and pathologies. Consequently, strategies for manipulation of the …