One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

BACKGROUND Most reproductive failures originate during the periconceptional period and
are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that …

The evidence that omega-3 (n-3) and-6 (n-6) polyunsaturated fatty acids (PUFAs) have
differential effects on ovarian function, oocytes and embryo quality is inconsistent. We report …

Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Anti-Müllerian hormone (AMH) is a multi-faceted gonadal cytokine. It is present in all
vertebrates with its original function in phylogeny being as a regulator of germ cells in both …

Maternal B-vitamin status at conception can affect fertility and the health of offspring. This
study details transcript expression for genes encoding key enzymes in the linked …

We previously reported increased follicular fluid progesterone (P4) concentrations in ewes
fed an n-3 compared to an n-6 polyunsaturated fatty acid (PUFA)-enriched diet, but detected …

Background Maternal smoking is one of the most important modifiable risk factors for low
birthweight, which is strongly associated with increased cardiometabolic disease risk in …

Epithelial cells of the endometrium secrete prostaglandins to regulate the bovine oestrous
cycle and form a functional barrier to microbes. However, bacterial infection of the …

abstract Background: Folate is a methyl donor. Availability of folate affects DNA methylation
profiles and thereby gene expression profiles. We investigated the effects of low-dose folic …