Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management

P Manu, L Dima, M Shulman… - Acta Psychiatrica …, 2015 - Wiley Online Library
Objective To review recent advances in the epidemiology, pathobiology, and management
of weight gain and obesity in patients with schizophrenia and to evaluate the extent to which …

Pharmacological management of glucose dysregulation in patients treated with second-generation antipsychotics

S Cernea, L Dima, CU Correll, P Manu - Drugs, 2020 - Springer
Fasting hyperglycemia, impaired glucose tolerance, prediabetes, and diabetes are
frequently present in patients treated with second-generation antipsychotics (SGAPs) for …

Antipsychotics-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives

R Singh, Y Bansal, B Medhi, A Kuhad - European journal of pharmacology, 2019 - Elsevier
Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses
by virtue of their advantage over typical antipsychotics ie least tendency of producing …

[HTML][HTML] Molecular mechanisms of antipsychotic drug-induced diabetes

J Chen, XF Huang, R Shao, C Chen… - Frontiers in …, 2017 - frontiersin.org
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As
mental disorders are chronic diseases, these drugs are often used over a life-time. However …

[HTML][HTML] Crosstalk between schizophrenia and metabolic syndrome: The role of oxytocinergic dysfunction

KK Goh, CYA Chen, TH Wu, CH Chen… - International journal of …, 2022 - mdpi.com
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …

Strategies to counter antipsychotic-associated weight gain in patients with schizophrenia

W Marteene, K Winckel, S Hollingworth… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Patients living with schizophrenia have a marked risk of clinically significant
weight gain and obesity compared to the general population. The risks have been …

[HTML][HTML] The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

R Zhou, M He, J Fan, R Li, Y Zuo, B Li, G Gao… - Frontiers in …, 2022 - frontiersin.org
Schizophrenia (SCZ) is a serious mental illness that affects 1% of people worldwide. SCZ is
associated with a higher risk of developing metabolic disorders such as obesity …

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

M He, Q Zhang, C Deng, H Wang, J Lian… - …, 2014 - Elsevier
Although second-generation antipsychotics induce severe weight gain and obesity, there is
a lack of detailed knowledge about the progressive development of antipsychotic-induced …

[HTML][HTML] Electrical stimulation with a conductive polymer promotes neurite outgrowth and synaptogenesis in primary cortical neurons in 3D

Q Zhang, S Beirne, K Shu, D Esrafilzadeh, XF Huang… - Scientific reports, 2018 - nature.com
Deficits in neurite outgrowth and synaptogenesis have been recognized as an underlying
developmental aetiology of psychosis. Electrical stimulation promotes neuronal induction …

[HTML][HTML] Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment

J Lian, XF Huang, N Pai, C Deng - PLoS One, 2014 - journals.plos.org
Olanzapine is the one of first line antipsychotic drug for schizophrenia and other serious
mental illness. However, it is associated with troublesome metabolic side-effects, particularly …