Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for
stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be …

In consideration of several serious side effects induced by the classical AF-2 involved “lock”
mechanism, recently disclosed PPARγ-Ser273 phosphorylation mode of action has become …

Introduction The analysis of the role of the mitochondria in oxidative damage and skin aging
has been a significant aspect of dermatological research. Mitochondria generate most …

This study introduces a novel cheminformatic read-across approach designed to identify
potential environmental obesogens, substances capable of disrupting metabolism and …

Adiponectin-synthesis-promoting compounds possess therapeutic potential to treat diverse
metabolic diseases, including obesity and diabetes. Phenotypic screening to find …

Peroxisome proliferator-activated receptors (PPARs) are associated with the regulation of
metabolic homeostasis. Based on a previous report that 1′-homologated 4 …

Inflammatory responses are fundamental protective warning mechanisms. However, in
certain instances, they contribute significantly to the development of several chronic …

In silico machine learning applications for phenotype-based screening have primarily been
limited due to the lack of machine-readable data related to disease phenotypes …

To determine which sugar conformation is favorable in binding to peroxisome proliferator-
activated receptors, the conformationally locked south (S) and north (N) analogues were …