Transition metal‐catalyzed dicarbofunctionalization of unactivated olefins
Transition metal (TM)‐catalyzed difunctionalization of unactivated olefins with two carbon‐
based entities is a powerful method to construct complex molecular architectures rapidly …
based entities is a powerful method to construct complex molecular architectures rapidly …
Multicomponent reactions with isocyanides
A Dömling, I Ugi - Angewandte Chemie International Edition, 2000 - Wiley Online Library
Multicomponent reactions (MCRs) are fundamentally different from two‐component
reactions in several aspects. Among the MCRs, those with isocyanides have developed into …
reactions in several aspects. Among the MCRs, those with isocyanides have developed into …
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
DA Horton, GT Bourne, ML Smythe - Chemical reviews, 2003 - ACS Publications
The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …
medicinal chemistry. These structures represent a class of molecules capable of binding to …
Concepts and applications of chemical fingerprint for hit and lead screening
J Yang, Y Cai, K Zhao, H Xie, X Chen - Drug Discovery Today, 2022 - Elsevier
Highlights•Providing concepts and generation processes of chemical fingerprints.•
Comparing the algorithms and characteristics among different types of fingerprints.• …
Comparing the algorithms and characteristics among different types of fingerprints.• …
Integration of virtual and high-throughput screening
J Bajorath - Nature Reviews Drug Discovery, 2002 - nature.com
High-throughput and virtual screening are important components of modern drug discovery
research. Typically, these screening technologies are considered distinct approaches, as …
research. Typically, these screening technologies are considered distinct approaches, as …
" Multi-component reactions: emerging chemistry in drug discovery"'from xylocain to crixivan'
C Hulme, V Gore - Current medicinal chemistry, 2003 - ingentaconnect.com
With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …
Privileged structures: efficient chemical “navigators” toward unexplored biologically relevant chemical spaces
In the search for new therapeutic agents for currently incurable diseases, attention has
turned to traditionally “undruggable” targets, and collections of drug-like small molecules …
turned to traditionally “undruggable” targets, and collections of drug-like small molecules …
Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
DJ Newman - Journal of medicinal chemistry, 2008 - ACS Publications
From approximately the early 1980s, the “influence of natural products” upon drug discovery
in all therapeutic areas apparently has been on the wane because of the advent of …
in all therapeutic areas apparently has been on the wane because of the advent of …
Molecular complexity and its impact on the probability of finding leads for drug discovery
Using a simple model of ligand− receptor interactions, the interactions between ligands and
receptors of varying complexities are studied and the probabilities of binding calculated. It is …
receptors of varying complexities are studied and the probabilities of binding calculated. It is …