The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Abstract Purpose of Review This review summarizes research on the physiological changes
that occur with aging and the resulting effects on fracture healing. Recent Findings Aging …

To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Alagille syndrome (ALGS) is an autosomal dominant, multisystem disorder with variable
phenotypic penetrance that was first described in 1969 by Daniel Alagille. Initial diagnosis …

Skeletal tissue development and regeneration in mammals are intricate, multistep, and
highly regulated processes. Various signaling pathways have been implicated in the …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems
and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation …

Fracture healing is a complex biological process that requires interaction among a series of
different cell types. Maintaining the appropriate temporal progression and spatial pattern is …

Fracture healing is a regenerative process that involves coordinated responses of many cell
types, but characterization of the roles of specific cell populations in this process has been …