[HTML][HTML] Pharmacogenomics: a genetic approach to drug development and therapy

R Qahwaji, I Ashankyty, NS Sannan, MS Hazzazi… - Pharmaceuticals, 2024 - mdpi.com
The majority of the well-known pharmacogenomics research used in the medical sciences
contributes to our understanding of medication interactions. It has a significant impact on …

Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation

B Khan, R Qahwaji, MS Alfaifi, T Athar, A Khan… - Scientific Reports, 2024 - nature.com
Breast cancer is caused by aberrant breast cells that proliferate and develop into tumors.
Tumors have the potential to spread throughout the body and become lethal if ignored …

[PDF][PDF] Systems-level understanding of toxicology and cardiovascular system

S Almowallad, R Jeet, M Mobashir - Jour. Bas. Sci, 2024 - researchgate.net
The extensive networks of molecular and functional alterations that take place at many
levels of biological structure are studied using traditional toxicology and quantitative …

An approach for systems-level understanding of prostate cancer from high-throughput data integration to pathway modeling and simulation

M Mobashir, SP Turunen, MA Izhari, IM Ashankyty… - Cells, 2022 - mdpi.com
To understand complex diseases, high-throughput data are generated at large and multiple
levels. However, extracting meaningful information from large datasets for comprehensive …

Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma

J Feng, J Wang, Y Xu, F Lu, J Zhang, X Han, C Zhang… - Plos one, 2023 - journals.plos.org
Background The purpose of this study was to develop a new prognostic model for
osteosarcoma based on cuproptosis-mitochondrion genes. Materials and methods The data …

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies

AA Firouzjaei, SH Aghaee‐Bakhtiari… - Cell Biochemistry …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …

Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma

SA El-Kafrawy, MM El-Daly, LH Bajrai… - Frontiers in …, 2022 - frontiersin.org
Data integration with phenotypes such as gene expression, pathways or function, and
protein-protein interactions data has proven to be a highly promising technique for …

Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma

M Zhu, Y Li, Y Wang, P Lin, J Mi, W Zhong - European Journal of Medical …, 2023 - Springer
Objective The latest research proposed a novel copper-dependent programmed cell death
named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal …

Predicting congenital renal tract malformation genes using machine learning

M Kabir, HM Stuart, FM Lopes, E Fotiou, B Keavney… - Scientific Reports, 2023 - nature.com
Congenital renal tract malformations (RTMs) are the major cause of severe kidney failure in
children. Studies to date have identified defined genetic causes for only a minority of human …

The cuproptosis related genes signature predicts the prognosis and correlates with the immune status of clear cell renal cell carcinoma

P Sun, H Xu, K Zhu, M Li, R Han, J Shen, X Xia… - Frontiers in …, 2022 - frontiersin.org
Background: Clear cell renal cell carcinoma (CCRCC) has a high incidence and poor
prognosis. Cuproptosis, an independent pattern of cell death associated with copper, plays …