Background: The intersection of synthetic biology and biomaterials promises to enhance
safety and efficacy in novel therapeutics. Both fields increasingly employ Boolean logic …

Background The interplay between gut microbiota and tumor microenvironment (TME) in the
pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the …

Injectable hydrogels may be pre-formed through dynamic crosslinks, allowing for injection
and subsequent retention in the tissue by shear-thinning and self-healing processes …

The accumulation of reactive oxygen species (ROS) in the oxidative stress
microenvironment of diabetic wounds often results in delayed wound healing. In this study, a …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Recent advances in synthetic methods and monomer design have given access to precision
carbohydrate polymers that extend beyond native polysaccharides. In this article, we present …

Cyclic ketene acetals (CKAs) are among the most well-studied monomers for radical ring-
opening polymerization (rROP). However, ring-retaining side reactions and low reactivities …

Obesity is a major modifiable risk factor leading to neuroinflammation and
neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of …

Diabetic wound healing is a substantial clinical challenge, characterized by delayed
angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from …

Lentinan (LNT), a natural polysaccharide, has been reported to exhibit immunomodulatory
effects in the intestine after oral administration. Herein, we aimed to investigate the lymphatic …