Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle
is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are …

This review summarizes the current literature regarding the most discussed contraction‐
regulated moykines like IL‐6, IL‐15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP‐1 …

Diabetes mellitus is defined as a group of metabolic diseases that are associated with the
presence of a hyperglycemic state due to impairments in insulin release and/or function …

Proteins secreted by skeletal muscle, so called myokines, have been shown to affect muscle
physiology and additionally exert systemic effects on other tissues and organs. Although …

Metabolic conditions share a common low-grade inflammatory milieu, which represents a
key-factor for their ignition and maintenance. Exercise is instrumental for warranting …

Myokines are peptides produced and released by myocytes of muscle fibers that influence
physiology of muscle and other organs and tissues. They are involved in mediating the …

Objective Skeletal muscle is an important secretory organ, producing and releasing
numerous myokines, which may be involved in mediating beneficial health effects of …

Abstract Follistatin-like protein 1 (Fstl1) is a secreted glycoprotein of the follistatin family.
Fstl1 is secreted by C2C12 cells, and Akt1 over-expression in skeletal muscle leads to its …

Obesity is a growing epidemic worldwide and is a major risk factor for several chronic
diseases, including diabetes, kidney disease, heart disease, and cancer. Obesity often leads …

Sirtuins are NAD+‐dependent deacetylases that regulate a range of cellular processes.
Although diverse functions of sirtuins have been proposed, those functions of SIRT 6 and …