Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic
transcription factor, originally discovered as a transducer of signal from cell surface …

Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and …

Since their discovery as key mediators of cytokine signaling, considerable progress has
been made in defining the structure-function relationships of Signal Transducers and …

Abstract Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces
signaling through the STAT proteins. We report that one STAT family member, Stat3, is …

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic
transcription factors that transmit signals from the cell membrane to the nucleus. One family …

Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine‐addicted
cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed …

Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are
major inducers of vascular endothelial growth factor (VEGF), one of the most potent …