The synthesis of large numbers of antibiotics over the past three decades has caused
complacency about the threat of bacterial resistance. Bacteria have become resistant to …

In the last several years, the frequency and spectrum of antimicrobial-resistant infections
have increased in both the hospital and the community. Certain infections that are …

Sociological interest in pharmaceuticals has intensified, heightening awareness of
'pharmaceuticalization'. It is argued that pharmaceuticalization should be understood by …

This paper on the fluoroquinolone resistance epidemiology stratifies the data according to
the different prescription patterns by either primary or tertiary caregivers and by indication …

Tuberculosis remains the leading cause of death in the world from a single infectious
disease, although there is little knowledge of the mechanisms of its pathogenesis and …

Broad use of fluoroquinolones has been followed by emergence of resistance, which has
been due mainly to chromosomal mutations in genes encoding the subunits of the drugs' …

The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the
discovery of new antibacterials and resistance-modifying agents. Since the initial discovery …

Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections,
and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is …

Staphylococcus aureus can exemplify better than any other human pathogen the adaptive
evolution of bacteria in the antibiotic era, as it has demonstrated a unique ability to quickly …

Gram-positive bacteria are common causes of bloodstream and other infections in
hospitalized patients in the United States, and the percentage of nosocomial bloodstream …