Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

Cryptococcus species are a major cause of life-threatening infections in
immunocompromised and immunocompetent hosts. While most disease is caused by …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in
treating certain tumors has led to numerous studies exploring its potential application to treat …

The fungal genus Cryptococcus comprises a group of pathogens with considerable
phenotypic and genotypic diversity that can lead to cryptococcosis in both healthy and …

Chimeric antigen receptors (CARs) redirect T cells to recognize a specific target. CAR
components play a pivotal role in antigen specificity, structure stability, expression on cell …

The ability to genetically redirect the antigenic specificity of T cells using chimeric antigen
receptors (CAR) has led to unprecedented durable clinical remissions in human patients …

Cryptococcosis, a systemic mycosis that affects both the immunocompromised and
immunocompetent, is caused by the inhalation of dehydrated yeasts or fungal spores of …

Immunotherapy treatments aim to modulate the host's immune response to either mitigate it
in inflammatory/autoimmune disease or enhance it against infection or cancer. Among …

Invasive aspergillosis (IA) is a common and deadly mold infection in immunocompromised
patients. As morbidity and mortality of IA are primarily driven by poor immune defense …