The molecular mechanisms that regulate embryogenesis and cardiac development are
calibrated by multiple signal transduction pathways within or between different cell lineages …

The gut microbiota and its secreted metabolites play a significant role in cardiovascular and
musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) resemble fetal
cardiomyocytes and electrical stimulation (ES) has been explored to mature the …

Aims: The pathogenesis of diabetic cardiomyopathy (DCM) is complex and the detailed
mechanism remains unclear. Coagulation protease activated Protein C (aPC) has been …

Abstract Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by a CTG
triplet repeat expansion within the 3′ untranslated region of the DMPK gene. Expression of …

Although heart failure management has improved during recent years, cardiovascular
disease remains the leading cause of death worldwide, highlighting the need for better …

Transcription factors govern various functions in the cell such as proliferation, repair,
regenerative programs, etc. Currently, there are no available drugs on the market or …

In the diseased and remodelled heart, increased activity and expression of Ca2+/calmodulin‐
dependent protein kinase II (CaMKII), an excess of fibrosis, and a decreased electrical …

Under extreme environmental conditions such as hypoxia, insufficient nutrition, and glucose
deficiency, the acetyl-CoA synthetase 2 (ACSS2)-mediated acetyl-CoA synthesis pathway …

This study investigated a regulator of the adaptive response to exercise, MEF2, for its
broader effects in adult skeletal muscle. MEF2 function was required to maintain normal …