The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Cell proliferation and cell growth are two tightly linked processes, as the proliferation
program cannot be executed without proper accumulation of cell mass, otherwise …

Several proto-oncogenes and tumor suppressors regulate the production of ribosomes.
Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 …

Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite
current aggressive treatment regimens, the prognosis for high‐risk NB patients remains …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

The p53 tumor suppressor protein is involved in regulating a wide variety of stress
responses, from senescence and apoptosis to more recently discovered roles in allowing …

The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA,
is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP …

Errors in ribosome biogenesis can result in quantitative or qualitative defects in protein
synthesis and consequently lead to improper execution of the genetic program and the …

Ribosomal proteins (RPs) have gained much attention for their extraribosomal functions
particularly with respect to p53 regulation. To date, about fourteen RPs have shown to bind …

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar
stress by mediating binding of ribosomal proteins to MDM2, resulting in p53 accumulation …