With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …

Neurodegenerative disorders are characterized by the progressive loss of central and/or
peripheral nervous system neurons. Within this context, neuroinflammation comes up as one …

DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).
However, relationships between DNA damage accumulation, DNA damage response …

Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The
occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD …

Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons
(MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the …

Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease. Genetic
predisposition, epigenetic changes, aging and accumulated life-long environmental …

One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …

The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral
sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western …

Background Mitochondrial dysregulation and aberrant epigenetic mechanisms have been
frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis …