Abstract Serotonin [5-hydroxytryptamine (5-HT)] in the central nervous system and in the
periphery has long been considered to have an important role in the control of pain, for …

Background: The aim of this review was to identify the mechanisms by which serotonin
receptors involved at the central level are able to modulate the nociceptive response. Pain is …

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

This study examines key elements of glutamatergic transmission within sensory ganglia of
the rat. We show that the soma of primary sensory neurons release glutamate when …

Cross-talk between the immune-and nervous-system is considered an important biological
process in health and disease. Because mast cells are often strategically placed between …

Postoperative pain affects most patients after major surgery and can transition to chronic
pain. The considerable side effects and limited efficacy of current treatments underline the …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …

Background: Despite the extensive number of studies performed in the last 50 years, aimed
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …

This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on
noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following …