The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of
antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem …

Background Light chain (AL) amyloidosis stands as the most prevalent subtype of systemic
amyloidosis, encompassing a group of rare diseases. Here, we evaluated the scientific …

Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid
fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on …

Studies carried out in the last three decades have significantly advanced our knowledge
about the structural factors that drive the amyloid aggregation of the immunoglobulin light …

Aggregation of antibody light chain proteins is associated with the progressive disease light
chain amyloidosis. Patient‐derived amyloid fibrils are formed from light chain variable …

Immunoglobulin light chain (AL) amyloidosis involves the deposition of insoluble
monoclonal AL protein fibrils in the extracellular space of different organs leading to …

Amyloidoses are protein misfolding diseases in which monomeric protein misfolds into fibrils
and accumulates in different organs. In light chain (AL) amyloidosis, fibrils are formed from …

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid
fibrils derived from a particular antibody light chain protein. In addition, soluble oligomeric …

Nucleic acids have been found to prevent aggregation as chaperones, as well as act as co-
factors and promote aggregation of amyloidogenic proteins leading to various diseases …